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Biology and Pathogenesis of Rhabdo- and Filoviruses cover

Rhabdoviruses and Filoviruses are single-stranded, non-segmented, negative-strand RNA viruses, many of which cause significant morbidity and mortality in humans and animals. Certain members of these virus families have been used as excellent model systems to understand the molecular biology of replication, host responses to infections, and viral countermeasures. Rhabdoviruses have also been used as vaccine vectors as well as oncolytic agents.

Studies on Filoviruses have now provided significant insights into how they enter susceptible cells, replicate and cause disease, and also how they evade the host's immune mechanisms. This book addresses the most recent findings on Rhabdovirus and Filovirus structure, replication mechanisms, host cell responses to virus infections and viral countermeasures. Chapters on emerging viruses as well as approaches for therapeutic interventions have also been included.

This book represents an authoritative text that brings together the most recent advances on the cellular and molecular biology of Rhabdo- and Filoviruses, including mechanisms of pathogenesis.

Sample Chapter(s)
Foreword (50 KB)
Chapter 1: Overview of Rhabdo- and Filoviruses (116 KB)


Contents:
  • Overview of Rhabdo– and Filoviruses (Asit K Pattnaik and Michael A Whitt)
  • Rhabdovirus Structure (Ming Luo)
  • The Pathway of VSV Entry into Cells (Shem Johnson and Jean Gruenberg)
  • Rhabdovirus Glycoproteins (Yves Gaudin and Michael A Whitt)
  • VSV RNA Transcription and Replication (Jacques Perrault)
  • Host Cell Functions in Vesicular Stomatitis Virus Replication (Phat X Dinh, Anshuman Das, and Asit K Pattnaik)
  • Cytopathogenesis of Rhabdoviruses (Douglas S Lyles)
  • Assembly and Budding of Rhabdo– and Filoviruses (Ziying Han and Ronald N Harty)
  • Rhabdoviruses as Vaccine Vectors: From Initial Development to Clinical Trials (John K Rose and David K Clarke)
  • Oncolytic Rhabdoviruses (Nicole E Forbes and John C Bell)
  • Use of Rhabdoviruses to Study Neural Circuitry (Melanie Ginger, Guillaume Bony, Matthias Haberl, and Andreas Frick)
  • Evolution of Rhabdo– and Filoviruses (Isabel S Novella, John B Presloid, and R Travis Taylor)
  • Emerging Rhabdoviruses (Imke Steffen and Graham Simmons)
  • Rabies Virus Replication and Pathogenesis (Andrew W Hudacek and Matthias J Schnell)
  • Activation and Evasion of Innate Immune Response by Rhabdoviruses (Karl-Klaus Conzelmann)
  • Rabies Virus Vaccines (Ying Huang, Clement W Gnanadurai, and Zhen F Fu)
  • Filovirus Structure and Morphogenesis (Timothy F Booth, Daniel R Beniac, Melissa J Rabb, and Lindsey L Lamboo)
  • Epidemiology and Pathogenesis of Filovirus Infections (Logan Banadyga and Hideki Ebihara)
  • Filovirus Entry into Susceptible Cells (Rohit K Jangra, Eva Mittler, and Kartik Chandran)
  • Filovirus Transcription & Replication (Kristina Brauburger, Laure R Deflubé, and Elke Muhlberger)
  • Innate Immune Evasion Mechanisms of Filoviruses (Christopher F Basler, Gaya K Amarasinghe, and Daisy W Leung)
  • Vaccines and Antivirals for Filoviruses (Chad E Mire and Thomas W Geisbe)

Readership: Investigators, graduate students, and post-graduate researchers in the field of RNA virology.

Free Access
FRONT MATTER
  • Pages:i–x

https://doi.org/10.1142/9789814635349_fmatter

No Access
CHAPTER 1: OVERVIEW OF RHABDO- AND FILOVIRUSES
  • Pages:1–13

https://doi.org/10.1142/9789814635349_0001

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CHAPTER 2: RHABDOVIRUS STRUCTURE
  • Pages:15–32

https://doi.org/10.1142/9789814635349_0002

No Access
CHAPTER 3: THE PATHWAY OF VSV ENTRY INTO CELLS
  • Pages:33–47

https://doi.org/10.1142/9789814635349_0003

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CHAPTER 4: RHABDOVIRUS GLYCOPROTEINS
  • Pages:49–73

https://doi.org/10.1142/9789814635349_0004

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CHAPTER 5: VSV RNA TRANSCRIPTION AND REPLICATION
  • Pages:75–105

https://doi.org/10.1142/9789814635349_0005

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CHAPTER 6: HOST CELL FUNCTIONS IN VESICULAR STOMATITIS VIRUS REPLICATION
  • Pages:107–139

https://doi.org/10.1142/9789814635349_0006

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CHAPTER 7: CYTOPATHOGENESIS OF RHABDOVIRUSES
  • Pages:141–169

https://doi.org/10.1142/9789814635349_0007

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CHAPTER 8: ASSEMBLY AND BUDDING OF RHABDO- AND FILOVIRUSES
  • Pages:171–197

https://doi.org/10.1142/9789814635349_0008

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CHAPTER 9: RHABDOVIRUSES AS VACCINE VECTORS: FROM INITIAL DEVELOPMENT TO CLINICAL TRIALS
  • Pages:199–230

https://doi.org/10.1142/9789814635349_0009

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CHAPTER 10: ONCOLYTIC RHABDOVIRUSES
  • Pages:231–261

https://doi.org/10.1142/9789814635349_0010

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CHAPTER 11: USE OF RHABDOVIRUSES TO STUDY NEURAL CIRCUITRY
  • Pages:263–287

https://doi.org/10.1142/9789814635349_0011

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CHAPTER 12: EVOLUTION OF RHABDO- AND FILOVIRUSES
  • Pages:289–310

https://doi.org/10.1142/9789814635349_0012

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CHAPTER 13: EMERGING RHABDOVIRUSES
  • Pages:311–334

https://doi.org/10.1142/9789814635349_0013

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CHAPTER 14: RABIES VIRUS REPLICATION AND PATHOGENESIS
  • Pages:335–351

https://doi.org/10.1142/9789814635349_0014

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CHAPTER 15: ACTIVATION AND EVASION OF INNATE IMMUNE RESPONSE BY RHABDOVIRUSES
  • Pages:353–385

https://doi.org/10.1142/9789814635349_0015

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CHAPTER 16: RABIES VIRUS VACCINES
  • Pages:387–426

https://doi.org/10.1142/9789814635349_0016

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CHAPTER 17: FILOVIRUS STRUCTURE AND MORPHOGENESIS
  • Pages:427–451

https://doi.org/10.1142/9789814635349_0017

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CHAPTER 18: EPIDEMIOLOGY AND PATHOGENESIS OF FILOVIRUS INFECTIONS
  • Pages:453–486

https://doi.org/10.1142/9789814635349_0018

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CHAPTER 19: FILOVIRUS ENTRY INTO SUSCEPTIBLE CELLS
  • Pages:487–514

https://doi.org/10.1142/9789814635349_0019

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CHAPTER 20: FILOVIRUS TRANSCRIPTION AND REPLICATION
  • Pages:515–555

https://doi.org/10.1142/9789814635349_0020

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CHAPTER 21: INNATE IMMUNE EVASION MECHANISMS OF FILOVIRUSES
  • Pages:557–586

https://doi.org/10.1142/9789814635349_0021

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CHAPTER 22: VACCINES AND ANTIVIRALS FOR FILOVIRUSES
  • Pages:587–620

https://doi.org/10.1142/9789814635349_0022