Evidence-Based Handbook of Neonatology

The following sections are included:

• Foreword

• Preface

• List of Contributors

• Contents

The following sections are included:

• Introduction

• The Impact and Etiology of Birth Defects

• Screening Versus Diagnosis of Genetic Disorders

• Chromosomal Abnormalities

• Maternal Serum Screening

• Fetus with Major Structural Defects Identified by Ultrasonography

• Single-Gene Disorders

• Hereditary Unstable DNA

• Multifactorial Disorders

• Invasive Fetal Testing

• Pre-implantation Genetic Diagnosis (Embryo Biopsy)

• Future Direction and New Therapies Under Investigation

• References

The following sections are included:

• Introduction

• The Evidence: Pitfalls in Assigning Teratogenicity

• Medications Specific to Pregnancy

• Other Medications

• References

The following sections are included:

• Definition/Concept

• Pathophysiology of Asphyxia

• Action Plan for Delivery Resuscitation

• Airway and Breathing

• Circulation

• Medication and Fluids

• General Supportive Management

• Ethical Issues

• References

The following sections are included:

• Introduction

• Adaptation to Extrauterine Life

• Factors Affecting Normal Transition

• Delivery Room Management

• References

The following sections are included:

• Evaluation of the Infant

• Differential Diagnosis

• References

The following sections are included:

• Introduction

• Changes in Clinical Presentation

• Changes in Understanding of BPD Pathogenesis

• Promising Therapies for Prevention and Treatment

• Conclusion

• References

The following sections are included:

• Pulmonary Mechanics

• Nasal CPAP

• Noninvasive Ventilation

• Conventional Ventilation

• Volume Limited Ventilation

• High-Frequency Ventilation

• Inhaled Nitric Oxide (iNO)

• Surfactant Therapy

• Permissive Hypercapnia (PHC)

• Respiratory Stimulants — Methylxanthines and Doxapram

• References

The following sections are included:

• Acyanotic Congenital Heart Disease

• Cyanotic Heart Disease in the Newborn

• References

The following sections are included:

• Introduction

• Diagnosis

• Incidence

• Pathophysiology: Regulation of Ductus Arteriosus Patency and Closure

• Pathophysiology: Hemodynamic and Pulmonary Alterations of a PDA

• Treatment

• Evidence-Based Management: PDA and Neonatal Morbidity — To Treat or Not to Treat

• Reference

The following sections are included:

• Necrotizing Enterocolitis

• Short Bowel Syndrome

• Gastro-Esophageal Reflux

• Cholestasis in Neonates

• Biliary Atresia

• References

The following sections are included:

• Erythropoiesis and Changing Hemoglobin Function

• Anemia

• Polycythemia

• Thrombocytopenia and Platelet Disorders

• References

The following sections are included:

• Introduction

• Poor Epidermal Barrier

• Pulmonary Edema Formation

• Electrolyte Imbalances and Neurodevelopment

• Areas for Investigation and Suggestions for Clinical Management

• Final Thoughts

• References

The following sections are included:

• Introduction

• Goals for Nutrient Intakes

• Parenteral Nutrition (PN)

• Enteral Nutrition

• Water

• Energy

• Carbohydrate

• Protein

• Lipids

• Minerals

• Trace Elements

• Vitamins

• References

The following sections are included:

• Introduction

• Perinatal Mineral Metabolism

• Neonatal Hypocalcemia

• Neonatal Hypercalcemia

• References

The following sections are included:

• Introduction

• Diagnostic Process and Considerations

• Pathophysiology

• Management of the Jaundiced Neonate

• References

The following sections are included:

• Neonatal Infections

• Congenital Infections

• Early-Onset Sepsis (EOS)

• Late-Onset Sepsis (LOS)

• Diagnostic Evaluation

• Treatment

• Prevention

• Neurodevelopmental Outcome and Sepsis

• References

The following sections are included:

• Introduction

• Neonatal Intracranial Hemorrhage (ICH) in Preterm Infants

• Periventricular Leucomalacia (PVL)

• Neonatal Hypoxic-Ischemic Encephalopathy in Term Infants

• References

The following sections are included:

• Introduction

• Pathogenesis

• Treatment

• Conclusions

• References

The following sections are included:

• Prenatal Diagnosis of Surgical Conditions

• Neonatal Surgery

• The EXIT Procedure

• Neonatal Surgery for Congenital Anomalies

• Abdominal Conditions

• References

The following sections are included:

• Rationale for Follow-Up of Infants cared for in a Neonatal Intensive Care Unit

• Objectives of a Follow-Up Program

• Staff and Procedures of the Follow-Up Program

• Risk Populations for Follow-Up

• Assessment Schedules

• Compliance for Follow-Up

• Outcomes and Assessments

• Summary

• References

The following sections are included:

• Introduction

• Discharge Criteria

• Follow-Up Care

• Corrected vs Chronologic Age

• Growth, Nutrition and Feeding

• Apnea of Prematurity

• Bronchopulmonary Dysplasia/Chronic Lung Disease

• Gastroesophageal Reflux

• Inguinal Hernias and Hydroceles

• Neurologic and Neurosensory Sequelae

• Other Complications

• Health Maintenance

• Technology Dependence

• Palliative Care

• Conclusions

• References

The following sections are included:

• Index