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Nitrobenzene method: A keystone in meso-substituted halogenated porphyrin synthesis and applications

Coimbra Chemistry Centre, CQC, Department of Chemistry, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal

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Carolina S. Vinagreiro

Coimbra Chemistry Centre, CQC, Department of Chemistry, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal

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Vanessa A. Tomé

Coimbra Chemistry Centre, CQC, Department of Chemistry, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal

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Giusi Piccirillo

Coimbra Chemistry Centre, CQC, Department of Chemistry, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal

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Liliana Damas

Coimbra Chemistry Centre, CQC, Department of Chemistry, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal

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, and

Mariette M. Pereira

Coimbra Chemistry Centre, CQC, Department of Chemistry, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal

E-mail Address: [email protected]

Correspondence to: Mariette M. Pereira, Department of Chemistry, Faculty of Science and Technology, University of Coimbra, Rua Larga, 3004-535, Coimbra, Portugal.

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https://doi.org/10.1142/S1088424619300039Cited by:10 (Source: Crossref)

Abstract

This review article briefly describes the available synthetic approaches for meso-arylporphyrins giving particular emphasis for one-pot nitrobenzene and nitrobenzene/NaY methods regarding the synthesis of meso-halogenated arylporphyrins. The review also describes the relevant applications of these halogenated porphyrins and their metalloporphyrin counterparts, prepared via nitrobenzene method, as photosensitizers for therapy (PDT and PDI), diagnostic (molecular contrast agents) and also for catalytic oxidation and CO₂ cycloaddition reactions to epoxides.

This paper is part of the 2019 Women in Porphyrin Science special issue.

Keywords:

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