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EMERGING CONCEPTS OF BRAIN FUNCTION

    For over 40 years, since I first obtained evidence for nonsynaptic diffusion neurotransmission (most scientists call it Volume Transmission), I have been convinced that we scientists were ignoring organizational dynamics other than the mechanistic synaptic organization of the brain. For many years it was an uneasy feeling, since I was aware there are so many avenues to explore in brain function. I have wondered how much we scientists have ignored, in our quest to understand how the brain really works, due to our efforts to "be scientific". In addition to the difficulty of understanding how the brain functions, how could we even begin to explore the human experience? In this paper I will first discuss some emerging concepts of brain function. I will then comment on the development of concepts that have been a part of my own research experience.

    References

    • M. J. Aguilar, Amer. J. Physical Med. 48, 279 (1969). MedlineGoogle Scholar
    • G. L. Aiello and P. Bach-y-Rita, Neuroreport 8, 1165 (1997). Crossref, Medline, ISIGoogle Scholar
    • G. L. Aiello and P. Bach-y-Rita, J. Neurosci. Meth. 103, 145 (2000). Crossref, Medline, ISIGoogle Scholar
    • G. L. Aiello and P. Bach-y-Rita, Intelligent Engineering Systems through Artificial Neural Networks Volume 11, eds. C. H. Dagliet al. (ASME Press, New York, 2001) pp. 441–447. Google Scholar
    • P. Bach-y-Rita, Exp. Neurol. 9, 327 (1964). Crossref, Medline, ISIGoogle Scholar
    • P. Bach-y-Rita, Acta. Neurol. Scand. 43, 417 (1967). Crossref, Medline, ISIGoogle Scholar
    • P.   Bach-y-Rita , Brain Mechanisms in Sensory Substitution ( Academic Press , New York , 1972 ) . Google Scholar
    • P. Bach-y-Rita, Recovery of Function: Theoretical Considerations for Brain Injury Rehabilitation, ed. P. Bach-y-Rita (Hans Huber, Berne Switzerland, 1980) pp. 225–263. Google Scholar
    • P. Bach-y-Rita, Scand. J. Rehabil. Med. 13, 73 (1981). MedlineGoogle Scholar
    • P. Bach-y-Rita, Rehabilitation Medicine, ed. J. Goodgold (CV Mosby Co., St. Louis MO, 1988) pp. 113–118. Google Scholar
    • P. Bach-y-Rita, Eur. Med. Phys. 25, 107 (1989). ISIGoogle Scholar
    • P. Bach-y-Rita, Volume Transmission in the Brain, eds. K. Fuxe and L. F. Agnati (Raven Press, New York, 1991) pp. 489–496. Google Scholar
    • P. Bach-y-Rita, Neuroreport 4, 343 (1993). Crossref, Medline, ISIGoogle Scholar
    • P. Bach-y-Rita, Neuroreport 5, 1553 (1994). Crossref, Medline, ISIGoogle Scholar
    • P. Bach-y-Rita, Science 264, 642 (1994). Crossref, Medline, ISIGoogle Scholar
    • P.   Bach-y-Rita , Nonsynaptic Diffusion Neurotransmission and Late Brain Reorganization ( Demos Publications , New York , 1995 ) . Google Scholar
    • P. Bach-y-Rita, Restor. Neurol. Neuros. 10, 1 (1996). Medline, ISIGoogle Scholar
    • P. Bach-y-Rita, P. W. Pharmacol. Soc. 41, 211 (1998). MedlineGoogle Scholar
    • P. Bach-y-Rita, Spinal Cord 37, 465 (1999). Crossref, Medline, ISIGoogle Scholar
    • P. Bach-y-Rita, Neuroplasticity and Reorganization of Function after Brain Injury, eds. H. Levin and J. Grafman (Oxford University Press, New York, 2000) pp. 357–379. Google Scholar
    • P. Bach-y-Rita, Top Stroke Rehabil. 8, 1 (2001). Google Scholar
    • P. Bach-y-Rita, Evol. Cognition 8, 115 (2002). ISIGoogle Scholar
    • P. Bach-y-Rita, Encyclopedia of the Human Brain Vol 1, ed. V. S. Ramachandran (Academic Press, New York, 2002) pp. 481–491. CrossrefGoogle Scholar
    • P. Bach-y-Rita, J. Integr. Neurosci. 3, 3 (2004). Link, ISIGoogle Scholar
    • P. Bach-y-Rita and G. L. Aiello, Neuroreport 7, 1502 (1996). Crossref, Medline, ISIGoogle Scholar
    • P. Bach-y-Rita and G. L. Aiello, Brain Behav. Sci. 24, 280 (2001). Crossref, ISIGoogle Scholar
    • P. Bach-y-Ritaet al., Nature 221, 963 (1969). Crossref, Medline, ISIGoogle Scholar
    • P. Bach-y-Rita and B. Hughes, Electronic Spatial Sensing for the Blind, eds. D. Warren and E. Strelow (Martinus-Nijhoff, Dordrecht the Netherlands, 1985) pp. 171–186. CrossrefGoogle Scholar
    • P. Bach-y-Rita and S. W. Kercel, Intellectica 35, 287 (2002). Google Scholar
    • P.   Bach-y-Rita and S. W.   Kercel , A novel strategy for coupling data into the human nervous system , Proceedings of the Fourth International Topical Meeting on Nuclear Plant Instrumentation, Control and Human-Machine Interface Technology , eds. J. M.   O'Hara and G.   Johnson ( American Nuclear Society , LaGrange Park IL , 2004 ) . Google Scholar
    • P. Bach-y-Rita and C. U. M. Smith, Scand. J. Rehabil. Med. 25, 3 (1993). MedlineGoogle Scholar
    • P. Bach-y-Rita and E. Wicab-Bach-y-Rita, Can. J. Psychology 44, 148 (1990). Crossref, Medline, ISIGoogle Scholar
    • P. Bach-y-Rita and E. Wicab-Bach-y-Rita, Arch. Phys. Med. Rehabil. 71, 1084 (1990). Medline, ISIGoogle Scholar
    • P. Bach-y-Ritaet al., Top Stroke Rehabil. 8, 1 (2002). Google Scholar
    • A. A. Beaton, Cortex 38, 479 (2002). Crossref, Medline, ISIGoogle Scholar
    • A. Beaudet and L. Descarries, Neuroscience 3, 851 (1978). Crossref, Medline, ISIGoogle Scholar
    • P. Broca, Bull. Soc. Anthropol. 4, 200 (1863). Google Scholar
    • S. Ry.   Cajal , Recollections of My Life ( MIT Press , Cambridge MA , 1989 ) . CrossrefGoogle Scholar
    • K. L. Chow and D. L. Stewart, Exp. Neurol. 34, 409 (1972). Crossref, Medline, ISIGoogle Scholar
    • E.   Clarke and C. D.   O'Malley , The Human Brain and Spinal Cord ( University of California Press , Berkeley , 1968 ) . Google Scholar
    • A. Coganet al., Pong game as a rehabilitation device, Proceedings of the Fourth Annual Conference on Systems and Devices for the Disabled, ed. C. G. Warren (University of Washington School of Medicine, Seattle WA, 1977) pp. 187–188. Google Scholar
    • V. A. Colotla and P. Bach-y-Rita, Cogn. Affect Behav. Neurosci. 2, 141 (2002). Crossref, Medline, ISIGoogle Scholar
    • J. D. De Keyser, G. Ebinger and G. Vauquelin, Neurosci. Lett. 104, 281 (1989). Crossref, Medline, ISIGoogle Scholar
    • D. C.   Dennett , Consciousness Explained ( Penguin Books , London , 1993 ) . Google Scholar
    • I. Dietzelet al., Exp. Brain Res. 40, 432 (1980). Medline, ISIGoogle Scholar
    • I. Dietzel and U. Heinemann, Ann. NY Acad. Sci. 481, 72 (1986). Crossref, Medline, ISIGoogle Scholar
    • G. M.   Edelman , Bright Air, Brilliant Fire ( Basic Books , New York , 1992 ) . Google Scholar
    • S. I. Franz, M. E. Scheetz and A. A. Wilson, J. Amer. Med. Assoc. 24, 2150 (1915). Google Scholar
    • W. J. Freeman, Neurobiology of Learning and Memory, eds. G. Lynch, J. L. McGaugh and N. M. Weinberger (Guilford Press, New York, 1984) pp. 231–234. Google Scholar
    • W. J. Freeman, Induced Rhythms in the Brain, eds. E. Basar and T. H. Bulloch (Birkhaüser, Boston, 1992) pp. 183–199. CrossrefGoogle Scholar
    • W. J. Freeman, Int. J. Bifurcat. Chaos 2, 451 (1992). LinkGoogle Scholar
    • W. J.   Freeman , Societies of Brains: A Study in the Neuroscience of Love and Hate ( Lawrence Erlbaum Associates , New York , 1995 ) . Google Scholar
    • K.   Fuxe and L. F.   Agnati , Volume Transmission in the Brain: Novel Mechanisms for Neural Transmission ( Raven Press , New York , 1991 ) . Google Scholar
    • A. Gibbons, Science 280, 1345 (1998). Crossref, Medline, ISIGoogle Scholar
    • J. J.   Gibson , The Senses Considered as Perceptual Systems ( Houghton Mifflin , Boston , 1966 ) . Google Scholar
    • C. D. Gilbert, J. A. Hirsch and T. N. Weisel, Cold Spring Harb. Sym. 55, 663 (1990). Crossref, Medline, ISIGoogle Scholar
    • C. D. Gilbert and T. N. Wiesel, Nature 356, 150 (1992). Crossref, Medline, ISIGoogle Scholar
    • A. V. Harreveld and F. I. Khattab, J. Neurophysiol. 30, 911 (1967). Crossref, MedlineGoogle Scholar
    • D. O.   Hebb , The Organization of Behavior ( John Wiley & Sons , New York , 1949 ) . Google Scholar
    • J.   Heil , Perception and Cognition ( University of California Press , Berkeley , 1983 ) . Google Scholar
    • M. Herkenham, Neuroscience 23, 1 (1987). Crossref, Medline, ISIGoogle Scholar
    • D. Horrobin, The Scientist 4, 13 (1990). Google Scholar
    • D. H. Hubel and T. N. Wiesel, J. Physiol. London 206, 419 (1970). CrossrefGoogle Scholar
    • S. W. Kercel, Evol. Cognition 8, 130 (2002). Google Scholar
    • S. W. Kercel, Softer than soft computing, Proceedings of the 2003 IEEE International Workshop on Soft Computing in Industrial Applications, ed. S. W. Kercel (IEEE, Piscataway NJ, 2003) pp. 27–32. Google Scholar
    • S. W. Kercel, J. Integr. Neurosci. 3, 61 (2004). LinkGoogle Scholar
    • S. W. Kercel, J. Integr. Neurosci. 3, 7 (2004). LinkGoogle Scholar
    • S. W.   Kercel , W. W.   Manges and A. S.   Reber , Wiring a human-in-the-loop , Proceedings of the Fourth International Topical Meeting on Nuclear Plant Instrumentation, Control and Human-Machine Interface Technology , eds. J. M.   O'Hara and G.   Johnson ( American Nuclear Society , LaGrange Park IL , 2004 ) . Google Scholar
    • R. Kuperset al., Neuroimage 19, S65 (2003). Google Scholar
    • S. B. Laughlin, R. R. de Ruyter van Stevenick and J. C. Anderson, Nat. Neurosci. 1, 36 (1998). Crossref, Medline, ISIGoogle Scholar
    • S. A. Lipton and S. B. Kater, Trends Neurosci. 12, 265 (1989). Crossref, Medline, ISIGoogle Scholar
    • A. R.   Luria , Restoration of Function After Brain Damage ( Macmillan , New York , 1963 ) . Google Scholar
    • R. K. Merton, Social Theory and Social Structure, ed. R. K. Merton (Free Press, New York, 1968) pp. 475–490. Google Scholar
    • G. A. Miller, Psychol. Rev. 63, 81 (1956). Crossref, Medline, ISIGoogle Scholar
    • G. Mitchison, Trends Neurosci. 15, 122 (1992). Crossref, Medline, ISIGoogle Scholar
    • M. J.   Morgan , Molyneux's Question ( Cambridge University Press , Cambridge , 1977 ) . Google Scholar
    • K. Murata, H. Cramer and P. Bach-y-Rita, J. Neurophysiol. 28, 1223 (1965). Crossref, Medline, ISIGoogle Scholar
    • C. Nicholson, Volume Transmission Revisited, Progress in Brain Research 125, eds. L. Agnatiet al. (Elsevier, Oxford, 2000) pp. 437–446. CrossrefGoogle Scholar
    • C. Nicholson and J. M. Phillips, J. Physiol. London 321, 225 (1981). CrossrefGoogle Scholar
    • R.   Nieuwenhuys , Chemoarchitecture of the Brain ( Springer , Berlin , 1986 ) . Google Scholar
    • R. Nieuwenhuys, Volume Transmission Revisited, Progress in Brain Research 125, eds. L. Agnatiet al. (Elsevier, Oxford, 2000) pp. 49–128. CrossrefGoogle Scholar
    • J. Olds, K. F. Killam and P. Bach-y-Rita, Science 124, 265 (1956). Crossref, Medline, ISIGoogle Scholar
    • A. Sawa, M. V. Pletnikov and A. Kamiya, Trends Neurosci. 27, 294 (2004). Crossref, Medline, ISIGoogle Scholar
    • G. M.   Shepherd , Foundations of the Neuron Doctrine , History of Neuroscience   6 ( Oxford University Press , Oxford , 1991 ) . Google Scholar
    • C. S.   Sherrington , The Integrative Action of the Nervous System ( Yale University Press , New Haven CT , 1947 ) . Google Scholar
    • D. A.   Sholl , The Organization of the Cerebral Cortex ( John Wiley & Sons , New York , 1956 ) . Google Scholar
    • E. Taub, Neural Control of Locomotion, eds. R. Hermanet al. (Plenum, New York, 1976) pp. 675–705. CrossrefGoogle Scholar
    • M. E. Tyler, Y. Danilov and P. Bach-y-Rita, J. Integr. Neurosci. 2, 159 (2003). Link, ISIGoogle Scholar
    • E. S. Vizi, Prog. Neurobiol. 12, 181 (1979). Crossref, Medline, ISIGoogle Scholar
    • E. S. Vizi, Trends Pharmacol. Sci. 2, 172 (1980). ISIGoogle Scholar
    • E. S. Vizi, Volume Transmission in the Brain, eds. K. Fuxe and L. F. Agnati (Raven Press, New York, 1991) pp. 89–96. Google Scholar
    • E. S. Vizi, Pharmacol. Rev. 52, 63 (2000). Medline, ISIGoogle Scholar
    • P. D. Wall, Recovery of Function: Theoretical Considerations for Brain Injury Rehabilitation, ed. P. Bach-y-Rita (Hans Huber, Berne, Switzerland, 1980) pp. 91–105. Google Scholar
    • M. C. Wanet-Defalqueet al., Brain Res. 446, 369 (1988). Crossref, Medline, ISIGoogle Scholar
    • E. Westerberget al., J. Neurosci. 9, 798 (1989). Crossref, Medline, ISIGoogle Scholar
    • M. Zoliet al., Trends Pharmacol. Sci. 20, 142 (1999). Crossref, Medline, ISIGoogle Scholar