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Models nanocomplexes based on C $_{60}$ fullerene for creation of biologically active agents for medicine

Institute of High Technologies, Taras Shevchenko National University of Kyiv, 4-g Academician Glushkov Avenue, Kyiv 03022, Ukraine

National University of Kyiv-Mohyla Academy, 2 Skovorody vul., Kyiv 04070, Ukraine

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I. G. Vyshyvana

Institute of High Technologies, Taras Shevchenko National University of Kyiv, 4-g Academician Glushkov Avenue, Kyiv 03022, Ukraine

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H. M. Kuznietsova

Institute of High Technologies, Taras Shevchenko National University of Kyiv, 4-g Academician Glushkov Avenue, Kyiv 03022, Ukraine

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V. K. Rybalchenko

Institute of High Technologies, Taras Shevchenko National University of Kyiv, 4-g Academician Glushkov Avenue, Kyiv 03022, Ukraine

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S. P. Kruchinin

Bogolyubov Institute for Theoretical Physics, 14-6 Metrolohichna Street, Kyiv 03143, Ukraine

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O. I. Tykhoniuk

Department of Chemistry, Taras Shevchenko National University of Kyiv, 12 Lva Tolstoho Street, Kyiv 01033, Ukraine

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D. S. Milokhov

Department of Chemistry, Taras Shevchenko National University of Kyiv, 12 Lva Tolstoho Street, Kyiv 01033, Ukraine

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O. V. Khilyax

Department of Chemistry, Taras Shevchenko National University of Kyiv, 12 Lva Tolstoho Street, Kyiv 01033, Ukraine

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and

R. M. Melnyk

Corresponding author.

National University of Kyiv-Mohyla Academy, 2 Skovorody vul., Kyiv 04070, Ukraine

E-mail Address: [email protected]

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https://doi.org/10.1142/S0217984920400643Cited by:0

This article is part of the issue:

SPECIAL ISSUE: Electron Correlation in Superconductors and Nanostructures
Guest Editors: Sergei Kruchinin and Janez Bonča

Abstract

Complex drugs based on C $_{60}$ fullerence and pyrrole derivatives are promising for the development of antitumor and anti-inflammatory agents for use in targeted therapy, but have little efficiency in the synthesis of such complexes and have virtually no stable synthesis products with fullerene. The stability of the nanocomplex based on [60] PCBA and the intermediate compound based on “ $1 H$ -pyrrole-2,5-dione” effective for the synthesis of targeted therapeutic agents was investigated by means of numerical calculations. The application of quantum-chemical methods in the Gaussian package establishes the stability of the nanocomplex at human body temperatures, the possibility of using such complexes for further study of the therapeutic properties of the individual components of the decomposition products of the nanocomplex.

Keywords:

PACS: 87.15.-v, 87.15.A, 87.15.ag, 36.40.-c, 36.40.Qv

References

1. S. Reuter, S. C. Gupta, M. M. Chaturvedi and B. B. Aggarwal, Free Rad. Biol. Med. 49(11) (2010) 1603. https://doi.org/10.1016/j.freeradbiomed.2010.09.006 Crossref, ISI, Google Scholar
2. Z. Wang, Z. Li, Y. Ye, L. Xie and W. Li, Oxid. Med. Cell. Longev. 2016 (2016) 7891574. https://doi.org/10.1155/2016/7891574 Google Scholar
3. A. Medhat, S. Mansour, S. El-Sonbaty, E. Kandil and M. Mahmoud, Tumour. Biol. 39(7) (2017) 1010428317717259. https://doi.org/10.1177/1010428317717259 Crossref, Google Scholar
4. I. V. Byelinska, H. M. Kuznietsova, N. V. Dziubenko, O. V. Lynchak, Yu. I. Prylutskyy, O. A. Kyzyma, O. Ivankov, V. K. Rybalchenko, and U. Ritter, Mat. Sci. Eng. C93 (2018) 505. https://doi.org/10.1016/j.msec.2018.08.033 Crossref, Google Scholar
5. O. V. Lynchak, Yu. I. Prylutskyy, V. K. Rybalchenko, O. A. Kyzyma, D. Soloviov, V. V. Kostjukov, M. P. Evstigneev, U. Ritter and P. Scharff, Nanoscale Res. Lett. 12(8) (2017) 1. https://doi.org/10.1186/s11671-016-1775-0 ADS, Google Scholar
6. S. V. Prylutska, O. P. Matyshevska, I. I. Grynyuk, Yu. I. Prylutskyy, U. Ritter and P. Scharff, Mol. Cryst. Liq. Cryst. 468(1) (2007) 265, https://doi.org/10.1080/15421400701230105. Crossref, Google Scholar
7. A. Montellano, T. Da Ros, A. Bianco and M. Prato, Nanoscale 3 (2011) 4035, https://doi.org/10.1039/c1nr10783f. Crossref, ISI, ADS, Google Scholar
8. C.-M. Lin and T.-Y. Lu, Recent Patents on Nanotechnology 6 (2012) 105, https://doi.org.10.2174/187221012800270135. Crossref, ISI, Google Scholar
9. M. M. Medrek, F. Plucin’ski, and A. P. Mazurek, Acta Polon. Pharmaceutica 70 (2013) 659. ISI, Google Scholar
10. R. R. Panchuk, S. V. Prylutska, V. V. Chumak, N. R. Skorokhyd, L. V. Lehka, M. P. Evstigneev, Yu. I. Prylutskyy, W. Berger, P. Heffeter, P. Scharff, U. Ritter and R. S. Stoika, J. Biomed. Nanotechnol. 11(7) (2015) 1139, https://doi.org/10.1166/jbn.2015.2058. Crossref, ISI, Google Scholar
11. H. M. Kuznietsova, O. V. Lynchak, M. O. Danylov, I. P. Kotliar, and V. K. Rybal’chenko, Ukr. Biochem. J. 85(3) (2013) 74, https://dx.doi.org/10.15407/ubj85.03.074. Crossref, Google Scholar
12. H. M. Kuznietsova, M. S. Yena, I. P. Kotlyar, O. V. Ogloblya and V. K. Rybalchenko, Sci. World J. 2016 (2016) 2145753, http://dx.doi.org/10.1155/2016/2145753. Crossref, Google Scholar
13. J. ForesmanA. Frisch, Exploring Chemistry with Electronic Structure Methods, 3rd edn. (Gaussian, Inc., Wallingford, CT, 2015). Google Scholar
14. S. P. Repetsky, I. G. Vyshyvana, E. Ya. Kuznetsova, S. P. Kruchinin, Int. J. Mod. Phys. B 32 (2018) 1840030. Link, ADS, Google Scholar
15. S. P. Repetsky, I. G. Vyshyvana, S. P. Kruchinin, S. Bellucci, Sci. Rep. 8 (2018) 9123. Crossref, ADS, Google Scholar
16. S. P. Repetsky, I. G. Vyshyvana, Y. Nakazawa, S. P. Kruchinin, S. Bellucci, Materials 12 (2019) 524. Crossref, ADS, Google Scholar
17. J. L. Wike-Hooley, J. Haverman and H. S. Reinhold, Radiother. Oncol. 2 (1997) 343, https://doi.org/10.1016/S0167-8140(84)80077-8. Crossref, Google Scholar

Published: 9 July 2020

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Received 7 February 2020

Accepted 20 March 2020

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Models nanocomplexes based on C60 fullerene for creation of biologically active agents for medicine

Abstract

References

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Models nanocomplexes based on C $_{60}$ fullerene for creation of biologically active agents for medicine