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Oriental Herbal Medicine for Neurological Disorders in Children: An Overview of Systematic Reviews

Department of Pediatrics of Korean Medicine, Kyung Hee University, Korean Medicine Hospital at Gangdong, Seoul 05278, Republic of Korea

These authors contributed equally to this work.

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Chan-Young Kwon

Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea

These authors contributed equally to this work.

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Gyu Tae Chang

Department of Pediatrics of Korean Medicine, Kyung Hee University, Korean Medicine Hospital at Gangdong, Seoul 05278, Republic of Korea

Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea

E-mail Address: [email protected]

Correspondence to: Prof. Gyu Tae Chang, Department of Pediatrics of Korean Medicine, Kyung Hee University Korean Medicine Hospital at Gangdong, #892 Dongnam-ro, Gangdong-gu, Seoul 05278, Republic of Korea. Tel: (+82) 2-440-7126, Fax: (+82) 2-440-7143.

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https://doi.org/10.1142/S0192415X18500866Cited by:17 (Source: Crossref)

Abstract

Oriental herbal medicine (OHM) has been widely used in pediatric neurological disorders and has attracted attention as a safe and effective treatment. We aim to summarize and evaluate the evidence for OHM in pediatric neurological disorders for evidence-based decision-making. Without language restrictions, up-to-date research data were obtained from nine electronic databases. Systematic reviews (SRs) assessing the efficacy of OHM for pediatric neurological disorders were included. The methodological quality of each review was assessed using the AMSTAR instrument. The quality of evidence for the main findings was evaluated using the GRADE approach. Sixteen SRs comprising 169 randomized controlled trials with 19,542 participants were included. In epilepsy (six SRs, $n = 5, 341$ ), OHM as an adjunctive or alternative therapy to antiepileptic drugs showed higher clinical symptom improvements than did antiepileptic drugs alone. The Activities of Daily Living scale score was significantly higher in children with cerebral palsy (one SR, $n = 508$ ) when OHM was added to rehabilitation. There were inconsistent results for tic disorder (four SRs, $n = 9, 870$ ) and enuresis (two SRs, $n = 1, 995$ ) and unclear results for attention deficit hyperactivity disorder (two SRs, $n = 1, 261$ ) and autism spectrum disorder (one SR, $n = 567$ ). Eleven SRs reported adverse events, but no fatal adverse reaction was reported. The methodological quality of the included reviews was medium-to-high. The overall quality of evidence ranged from “very low” to “moderate.” In conclusion, the efficacy of OHM is promising for some pediatric neurological disorders such as epilepsy and cerebral palsy. However, more high-quality evidence is needed to make clinical recommendations on OHM use.

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References

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