Clinical Efficacy of Acupuncture as an Adjunct to Methadone Treatment Services for Heroin Addicts: A Randomized Controlled Trial
Abstract
Scant scientific evidence supports the efficacy of acupuncture in the treatment of opiate dependence. The purpose of this study was to examine the effectiveness of acupuncture for heroin addicts on methadone maintenance by measuring the daily consumption of methadone, variations in the 36-item Short Form Health Survey-36 (SF-36) and Pittsburgh Sleep Quality Index (PSQI) scores, and heroin craving. Sixty heroin addicts were randomly assigned to true acupuncture (electroacupuncture at the Hegu [LI4] and Zusanli [ST36] acupoints, as well as acupuncture at the Ear Shenmen) or sham acupuncture (minimal acupuncture at the Hegu and Zusanli acupoints without electrical stimulation and superficial acupuncture at the Ear Shenmen), twice weekly for 4 weeks. From week 2 onwards, the daily dose of methadone was reduced by a significantly greater amount with true acupuncture compared with sham acupuncture. True acupuncture was also associated with a greater improvement in sleep latency at follow-up. All adverse events were mild in severity. Acupuncture appears to be a useful adjunct to methadone maintenance therapy (MMT) in heroin addiction.
References
- Am. J. Psychiatry 151 , 735 ( 1994 ) . Google Scholar
- J. Stud. Alcohol Drugs 70 , 735 ( 2009 ) . Crossref, Medline, ISI, Google Scholar
- J. Subst. Abuse Treat. 36 , 345 ( 2009 ) . Crossref, Medline, ISI, Google Scholar
- J. Altern. Complement. Med. 10 , 468 ( 2004 ) . Crossref, Medline, ISI, Google Scholar
- Public Health 122 , 1013 ( 2008 ) . Crossref, Medline, ISI, Google Scholar
- J. Subst. Abuse Treat. 10 , 35 ( 1993 ) . Crossref, Medline, ISI, Google Scholar
- Lancet 1 , 1435 ( 1989 ) . Crossref, Medline, ISI, Google Scholar
- Alcohol. Clin. Exp. Res. 11 , 292 ( 1987 ) . Crossref, Medline, ISI, Google Scholar
- Psychiatry Res. 28 , 193 ( 1989 ) . Crossref, Medline, ISI, Google Scholar
- J. Altern. Complement. Med. 15 , 1171 ( 2009 ) . Crossref, Medline, ISI, Google Scholar
- Am. J. Chin. Med. 41 , 1233 ( 2013 ) . Link, ISI, Google Scholar
- Evid. Based Complement. Alternat. Med. 2013 , 134610 ( 2013 ) . Medline, Google Scholar
- Am. J. Chin. Med. 40 , 695 ( 2012 ) . Link, ISI, Google Scholar
- Lancet 2 , 380 ( 1979 ) . Crossref, Medline, ISI, Google Scholar
- J. Tradit. Chin. Med. 15 , 301 ( 1995 ) . Medline, Google Scholar
- J. Altern. Complement. Med. 2 , 161 ( 1996 ) . Crossref, Google Scholar
- Addiction 94 , 665 ( 1999 ) . Crossref, Medline, ISI, Google Scholar
- Psychopharmacology (Berl) 154 , 153 ( 2001 ) . Crossref, Medline, ISI, Google Scholar
- Addiction 89 , 211 ( 1994 ) . Crossref, Medline, ISI, Google Scholar
- Drug Alcohol Depend. 39 , 207 ( 1995 ) . Crossref, Medline, ISI, Google Scholar
- Addict. Behav. 24 , 707 ( 1999 ) . Crossref, Medline, ISI, Google Scholar
- Drug Alcohol Rev. 23 , 273 ( 2004 ) . Crossref, Medline, ISI, Google Scholar
- JAMA 193 , 646 ( 1965 ) . Crossref, Medline, ISI, Google Scholar
- IMJ. Ill. Med. J. 130 , 487 ( 1966 ) . Medline, Google Scholar
- NY State J. Med. 66 , 2011 ( 1966 ) . Medline, Google Scholar
- Addiction 100 , 1496 ( 2005 ) . Crossref, Medline, ISI, Google Scholar
- Addiction 100 , 1101 ( 2005 ) . Crossref, Medline, ISI, Google Scholar
- J. Addict. Dis. 30 , 27 ( 2011 ) . Crossref, Medline, ISI, Google Scholar
- Drug Alcohol Depend. 65 , 283 ( 2002 ) . Crossref, Medline, ISI, Google Scholar
- N. Engl. J. Med. 323 , 844 ( 1990 ) . Crossref, Medline, ISI, Google Scholar
- J. Physiol. 391 , 141 ( 1987 ) . Crossref, Medline, ISI, Google Scholar
- Trends Neurosci. 26 , 17 ( 2003 ) . Crossref, Medline, ISI, Google Scholar
- Neurosci. Lett. 361 , 258 ( 2004 ) . Crossref, Medline, ISI, Google Scholar
- Pain 152 , S41 ( 2011 ) . Crossref, Medline, ISI, Google Scholar
- Pain 47 , 295 ( 1991 ) . Crossref, Medline, ISI, Google Scholar
- Sheng Li Xue Bao 38 , 475 ( 1986 ) . Medline, Google Scholar
- Am. J. Public Health 85 , 83 ( 1995 ) . Crossref, Medline, ISI, Google Scholar
- Arch. Gen. Psychiatry 58 , 503 ( 2001 ) . Crossref, Medline, ISI, Google Scholar
- Behav. Res. Ther. 46 , 1170 ( 2008 ) . Crossref, Medline, ISI, Google Scholar
- Evid. Based Complement. Alternat. Med. 2 , 325 ( 2005 ) . Crossref, Medline, ISI, Google Scholar
- J. Addict. Dis. 28 , 219 ( 2009 ) . Crossref, Medline, ISI, Google Scholar
- Evid. Based Complement. Alternat. Med. 2011 , 361054 ( 2011 ) . Medline, Google Scholar
- Evid. Based Complement. Alternat. Med. 2012 , 739045 ( 2012 ) . Medline, Google Scholar
- Am. J. Chin. Med. 40 , 219 ( 2012 ) . Link, ISI, Google Scholar
- Am. J. Chin. Med. 39 , 1131 ( 2011 ) . Link, ISI, Google Scholar
- Arch. Gen. Psychiatry 53 , 401 ( 1996 ) . Crossref, Medline, ISI, Google Scholar
- J. Subst. Abuse Treat. 11 , 205 ( 1994 ) . Crossref, Medline, ISI, Google Scholar
- J. Psychoactive Drugs 37 , 385 ( 2005 ) . Crossref, Medline, ISI, Google Scholar
- Addiction 93 , 515 ( 1998 ) . Crossref, Medline, ISI, Google Scholar
- Addiction 98 , 441 ( 2003 ) . Crossref, Medline, ISI, Google Scholar
- Med. Care 31 , 247 ( 1993 ) . Crossref, Medline, ISI, Google Scholar
- JAMA 284 , 1689 ( 2000 ) . Crossref, Medline, ISI, Google Scholar
- Drug Alcohol Depend. 67 , 41 ( 2002 ) . Crossref, Medline, ISI, Google Scholar
- Acta Anaesthesiol. Sin. 40 , 173 ( 2002 ) . Medline, Google Scholar
- Zhongguo Zhen Jiu 25 , 599 ( 2005 ) . Medline, Google Scholar
- Evid. Based Complement. Alternat. Med. 2011 , 209879 ( 2011 ) . Crossref, Medline, ISI, Google Scholar
- Drug Alcohol Depend. 82 , 103 ( 2006 ) . Crossref, Medline, ISI, Google Scholar
- Drug Alcohol Depend. 104 , 228 ( 2009 ) . Crossref, Medline, ISI, Google Scholar
- Naunyn Schmiedebergs Arch. Pharmacol. 339 , 617 ( 1989 ) . Crossref, Medline, ISI, Google Scholar
- Arch Gen Psychiatry 42 , 1072 ( 1985 ) . Crossref, Medline, ISI, Google Scholar
- Arch Gen Psychiatry 39 , 161 ( 1982 ) . Crossref, Medline, ISI, Google Scholar
- Chin. Med. J. 122 , 2869 ( 2009 ) . Medline, ISI, Google Scholar
- Brain Res. 981 , 23 ( 2003 ) . Crossref, Medline, ISI, Google Scholar
- Eur. J. Pharmacol. 579 , 160 ( 2008 ) . Crossref, Medline, ISI, Google Scholar
- Pharmacol. Biochem. Behav. 87 , 141 ( 2007 ) . Crossref, Medline, ISI, Google Scholar
- J. Subst. Abuse Treat. 26 , 175 ( 2004 ) . Crossref, Medline, ISI, Google Scholar
- Qual. Life Res. 14 , 1943 ( 2005 ) . Crossref, Medline, ISI, Google Scholar
- Health Qual. Life Outcomes 1 , 72 ( 2003 ) . Crossref, Medline, Google Scholar
- Eur. Neuropsychopharmacol. 18 , 390 ( 2008 ) . Crossref, Medline, ISI, Google Scholar
- Neuroreport 11 , 1017 ( 2000 ) . Crossref, Medline, ISI, Google Scholar
- Anesth. Analg. 106 , 602 ( 2008 ) . Crossref, Medline, ISI, Google Scholar
- Neurosci. Lett. 494 , 49 ( 2011 ) . Crossref, Medline, ISI, Google Scholar
- Lancet 353 , 221 ( 1999 ) . Crossref, Medline, ISI, Google Scholar
- Med. Care 33 , AS264 ( 1995 ) . Crossref, Medline, ISI, Google Scholar
- Med. Care 30 , 473 ( 1992 ) . Crossref, Medline, ISI, Google Scholar
- J. Subst. Abuse Treat. 10 , 345 ( 1993 ) . Crossref, Medline, ISI, Google Scholar
- Am. J. Addict. 4 , 198 ( 1995 ) . Crossref, ISI, Google Scholar
- Zhongguo Zhen Jiu 25 , 449 ( 2005 ) . Medline, Google Scholar
- Res. Nurs. Health 13 , 227 ( 1990 ) . Crossref, Medline, ISI, Google Scholar
- Zhong Xi Yi Jie He Xue Bao 1 , 268 ( 2003 ) . Crossref, Medline, Google Scholar
- Brain Res. 851 , 290 ( 1999 ) . Crossref, Medline, ISI, Google Scholar
- Zhongguo Zhen Jiu 30 , 904 ( 2010 ) . Medline, Google Scholar
- Sleep Med. 10 , 694 ( 2009 ) . Crossref, Medline, ISI, Google Scholar
- Sleep 32 , 1039 ( 2009 ) . Crossref, Medline, ISI, Google Scholar
- Alcohol. Clin. Exp. Res. 25 , 63S ( 2001 ) . Crossref, Medline, ISI, Google Scholar
- J. Tradit. Chin. Med. 25 , 166 ( 2005 ) . Medline, Google Scholar
- Zhongguo Zhong Xi Yi Jie He Za Zhi 20 , 593 ( 2000 ) . Medline, Google Scholar
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