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Efficacy Comparison of Korean Ginseng and American Ginseng on Body Temperature and Metabolic Parameters

Eun-Young Park

College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Incheon, Korea

Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea

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Mi-Hwi Kim

College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Incheon, Korea

Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea

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Eung-Hwi Kim

College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Incheon, Korea

Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea

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Eun-Kyu Lee

College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Incheon, Korea

Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea

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In-Sun Park

Department of Pathology, Inha University Hospital, Inha University School of Medicine, Incheon, Korea

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Duck-Choon Yang

Korea Ginseng Center for Most Valuable Products and Ginseng Genetic Resource Bank, Kyung Hee University, Korea

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and

Hee-Sook Jun

College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Incheon, Korea

Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea

Gachon Medical Research Institute, Gil Hospital, Incheon, Korea

Correspondence to: Dr. Hee Sook Jun, PhD, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, 7-45 Sondo-dong, Yeonsu-ku, Incheon 406-840, Korea Tel: (+82) 32-899-6056, Fax: (+82) 32-899-6507.

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https://doi.org/10.1142/S0192415X14500128Cited by:24

Abstract

Ginseng has beneficial effects in cancer, diabetes and aging. There are two main varieties of ginseng: Panax ginseng (Korean ginseng) and Panax quinquefolius (American ginseng). There are anecdotal reports that American ginseng helps reduce body temperature, whereas Korean ginseng improves blood circulation and increases body temperature; however, their respective effects on body temperature and metabolic parameters have not been studied. We investigated body temperature and metabolic parameters in mice using a metabolic cage. After administering ginseng extracts acutely (single dose of 1000 mg/kg) or chronically (200 mg/kg/day for four weeks), core body temperature, food intake, oxygen consumption and activity were measured, as well as serum levels of pyrogen-related factors and mRNA expression of metabolic genes. Acute treatment with American ginseng reduced body temperature compared with PBS-treated mice during the night; however, there was no significant effect of ginseng treatment on body temperature after four weeks of treatment. VO₂, VCO₂, food intake, activity and energy expenditure were unchanged after both acute and chronic ginseng treatment compared with PBS treatment. In acutely treated mice, serum thyroxin levels were reduced by red and American ginseng, and the serum prostaglandin E2 level was reduced by American ginseng. In chronically treated mice, red and white ginseng reduced thyroxin levels. We conclude that Korean ginseng does not stimulate metabolism in mice, whereas a high dose of American ginseng may reduce night-time body temperature and pyrogen-related factors.

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Efficacy Comparison of Korean Ginseng and American Ginseng on Body Temperature and Metabolic Parameters

Abstract

References

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