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Curculigo orchioides Protects Cisplatin-Induced Cell Damage

Tong Ho Kang

College of Life Sciences, Kyung Hee University, Gyeonggi 446-701, South Korea

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Bin Na Hong

College of Life Sciences, Kyung Hee University, Gyeonggi 446-701, South Korea

Department of Audiology, Nambu University, Gwangju 506-706, South Korea

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Su-Young Jung

Department of Oral Biochemistry and Vestibulocochlear Research Center, School of Dentistry, Wonkwang University, Iksan 570-749, South Korea

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Jeong-Han Lee

Department of Anesthesiology and Pain Medicine, Program in Communication Science, School of Medicine, University of California, Davis, CA 95618, USA

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Hong-Seob So

Vestibulocochlear Research Center and Department of Microbiology, School of Medicine, Wonkwang University, Iksan 570-749, South Korea

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Raekil Park

Vestibulocochlear Research Center and Department of Microbiology, School of Medicine, Wonkwang University, Iksan 570-749, South Korea

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and

Yong-Ouk You

Department of Oral Biochemistry and Vestibulocochlear Research Center, School of Dentistry, Wonkwang University, Iksan 570-749, South Korea

Correspondence to: Dr. Yong-Ouk You, Department of Oral Biochemistry, School of Dentistry, Wonkwang University, 344-2 Shinyong-dong, Iksan, Jeonbuk, 570-749, South Korea. Tel: (+82) 63-850-6926, Fax: (+82) 63-850-6858.

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https://doi.org/10.1142/S0192415X13500316Cited by:4

Abstract

Cisplatin is commonly used as a chemotherapeutic agent against many human cancers. However, it generates reactive oxygen species (ROS) and has serious dose-limiting side effects, including ototoxicity. The roots of Curculigo orchioides (C. orchioides) have been used to treat auditory diseases such as tinnitus and hearing loss in Chinese traditional medicine. In the present study, we investigated the protective effects of an ethanol extract obtained from C. orchioides rhizome (COR) on cisplatin-induced cell damage in auditory cells (HEI-OC1). COR (2.5–25 μg/ml) inhibited cisplatin-induced HEI-OC1 cell damage in a dose-dependent manner. To investigate the protective mechanism of COR on cisplatin cytotoxicity in HEI-OC1 cells, we measured the effects of COR on ROS generation and lipid peroxidation in cisplatin-treated cells as well as its scavenging activities against superoxide radicals, hydroxyl radicals, hydrogen peroxide, and DPPH radicals. COR (1–25 μg/ml) had scavenging activities against superoxide radicals, hydroxyl radicals, hydrogen peroxide, and DPPH radicals, as well as reduced lipid peroxidation. In in vivo experiments, COR was shown to reduce cochlear and peripheral auditory function impairments through cisplatin-induced auditory damage in mice. These results indicate that COR protects from cisplatin-induced auditory damage by inhibiting lipid peroxidation and scavenging activities against free radicals.

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Curculigo orchioides Protects Cisplatin-Induced Cell Damage

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