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In Vitro Antioxidant and Antimicrobial Activity of Extracts from Morus alba L. Leaves, Stems and Fruits

Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China

Engineering Research Center of Forest Bio-Preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, China

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Yuangang Zu

Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China

Engineering Research Center of Forest Bio-Preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, China

Correspondence to: Dr. Y. Zu, Northeast Forestry University, Box 332, Hexing Road 26, Harbin 150040, China. Tel: (+86) 451-8219-1387, Fax: (+86) 451-8210-2082.

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Yujie Fu

Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China

Engineering Research Center of Forest Bio-Preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, China

Correspondence to: Dr. Y. Fu, Tel: (+86) 451-8219-0535, Fax: (+86) 451-8219-0535.

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, and

Thomas Efferth

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Mainz 55099, Germany

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https://doi.org/10.1142/S0192415X12500279Cited by:39

Abstract

In this study, the aqueous and ethanolic extracts (leaves, stems and fruits) from Morus alba L., a traditional Chinese medicine, were evaluated for their antioxidant and antimicrobial properties. Ethanolic extracts showed higher contents of both total phenolics and flavonoids than aqueous extracts. The total phenolic content was in the order of: leaf extracts > fruit extracts > stem extracts, whereas the total flavonoids was: leaf extracts > stem extracts > fruit extracts. Using DPPH assays, the concentrations providing 50% inhibition (IC₅₀) values of aqueous extracts from leaves, stems and fruits were 7.11 ± 1.45 mg/ml, 86.78 ± 3.21 mg/ml and 14.38 ± 2.83 mg/ml, respectively, whereas the IC₅₀ values of ethanolic extracts were 3.11 ± 0.86 mg/ml, 14.62 ± 2.45 mg/ml and 12.42 ± 2.76 mg/ml, respectively. In sum, the antioxidant activities of ethanolic extracts from M. alba L. were stronger than the aqueous extracts, and in the order of: leaf extracts > fruit extracts > stem extracts. The ethanolic extracts exhibited moderate antimicrobial activities, whereas the aqueous extracts showed poor antimicrobial properties in our test system. This study validated the medicinal potential of M. alba L.

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In Vitro Antioxidant and Antimicrobial Activity of Extracts from Morus alba L. Leaves, Stems and Fruits

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