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Antinociception of Heterotopic Electro-Acupuncture Mediated by the Dorsolateral Funiculus

Seung Jae Lee

The Institute of New Life Health Center, Boston, USA

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Yeoung Su Lyu

Department of Oriental Neuropsychiatry, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea

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Hyung Won Kang

Department of Oriental Neuropsychiatry, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea

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In Churl Sohn

Department of Meridian and Acupoint, Wonkwang University College of Oriental Medicine, Iksan, Jeonbuk 570-749, Republic of Korea

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Sungtae Koo

Department of Medical Research, Korea Institute of Oriental Medicine, 461-24 Jeonmin-Dong, Yuseong-gu, Daejeon 305-811, Republic of Korea

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Min Sun Kim

Department of Physiology, Iksan, Jeonbuk 570-749, Republic of Korea

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Byung Rim Park

Department of Physiology, Iksan, Jeonbuk 570-749, Republic of Korea

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Jeong Hoon Song

Department of Plastic and Reconstructive Surgery, Wonkwang University School of Medicine, and Hanbang Research Center at Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea

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and

Jae Hyo Kim

Department of Meridian and Acupoint, Wonkwang University College of Oriental Medicine, Iksan, Jeonbuk 570-749, Republic of Korea

Correspondence to: Dr. Jae Hyo Kim, Department of Meridian and Acupoint, Wonkwang University College of Oriental Medicine, Iksan, Jeonbuk 570-749, Republic of Korea. Tel: (+82) 63-850-6446, Fax: (+82) 63-857-6458.

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https://doi.org/10.1142/S0192415X07004795Cited by:14

Abstract

We investigated the inhibitory pathways that mediate the antinociceptive effects of heterotopic electro-acupuncture (EA) on formalin injection-induced pain in rats. EA (2 ms, 10 Hz, 3 mA) was delivered to heterotopic acupoints HT₇ and PC₇ for 30 min; this was followed immediately by subcutaneous injection of formalin into the left hind paw of rats. Naltrexone (10 mg/kg, i.p.), an opioid receptor antagonist, was administered to evaluate the involvement of endogenous opioids. The dorsolateral funiculus (DLF), which is a descending pathway that inhibits pain, was transected at the ipsilateral T10–11 level of the thoracic spinal cord. EA inhibited behavioral responses to formalin injection-induced pain and prevented the pain-induced increase in cFos expression in the lumbar spinal cord. Pretreatment with naltrexone did not inhibit the antinociceptive effects of EA on formalin injection-induced pain. Transection of the DLF ipsilateral to the acupuncture site eliminated the antinociceptive effects of EA. These results suggest that the antinociceptive effects of heterotopic EA are mediated by the DLF and not by endogenous opioids.

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Vol. 35, No. 02

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Antinociception of Heterotopic Electro-Acupuncture Mediated by the Dorsolateral Funiculus

Abstract

References

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