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Effects of Ginseng on the Proliferation of Human Lung Fibroblasts

Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan

College of Pharmacy, Seoul National University, Seoul 151-742, Korea

Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan

Correspondence to: Dr. Takako Yokozawa, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan. Fax: (+81) 76-434-5068.

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Akiko Satoh

Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan

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Ki Sung Kang

Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan

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, and

Hyun Young Kim

College of Pharmacy, Seoul National University, Seoul 151-742, Korea

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https://doi.org/10.1142/S0192415X06003709Cited by:14

Abstract

In this study, we investigated the effects of methanolic extracts of white ginseng (Panax ginseng C.A. MEYER) and two kinds of heat-treated ginseng made by steaming fresh ginseng at 100°C for 3 hours (HTG-100) or 120°C for 3 hours (HTG-120) on the cell growth of human fibroblasts. All of the tested ginseng extracts stimulated cell growth, although the effect of HTG-120 was weaker than that of the other extracts. However, none of the ginseng extracts exhibited any effect on the growth of old cells with a population doubling level (PDL) of 48.7. Flow cytometric analysis showed that ginseng extracts raised the population of cells in G₀/G₁ phase after treatment for 24 hours, but did not exert any effect after treatment for 48 hours. These results suggest that ginsengs exert their cell growth-promoting action mainly on younger cells at an early stage of the cell cycle, and that this effect is closely associated with an increase in the population of cells in the G₀/G₁ phase.

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Effects of Ginseng on the Proliferation of Human Lung Fibroblasts

Abstract

References

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