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The Ameliorating Effects of Cognition-enhancing Chinese Herbs on Scopolamine-and MK-801-induced Amnesia in Rats

Ying-Chih Lin

Institute of Chinese Pharmaceutical Sciences, China Medical College, 91, Hsieh Shih Road, Taichung, Taiwan, R.O.C.

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Chi-Rei Wu

Institute of Chinese Pharmaceutical Sciences, China Medical College, 91, Hsieh Shih Road, Taichung, Taiwan, R.O.C.

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Chun-Ju Lin

Institute of Chinese Pharmaceutical Sciences, China Medical College, 91, Hsieh Shih Road, Taichung, Taiwan, R.O.C.

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Ming-Tsuen Hsieh

Institute of Chinese Pharmaceutical Sciences, China Medical College, 91, Hsieh Shih Road, Taichung, Taiwan, R.O.C.

Correspondence to: Dr. Ming-Tsuen Hsieh, Institute of Chinese Pharmaceutical Sciences, China Medical College, 91, Hsieh Shih Road, Taichung, Taiwan, R.O.C. Fax: (+886) 4-2205-3958.

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https://doi.org/10.1142/S0192415X03001302Cited by:12 (Source: Crossref)

Abstract

The study was to investigate the ameliorating effects of three Chinese herbs — Achyranthes bidentata (AB), Ophiopogon japonicus (OJ) and Cnidium monnieri (CM) on scopolamine (SCOP)- and MK-801-induced amnesia by using a passive avoidance task in rats. AB, OJ and CM at 0.1 and 0.3 g/kg prolonged the step-through latency (STL) of the retention trial. In addition, AB, OJ and CM reversed the STL shortened by MK-801, but only AB reversed the STL shortened by SCOP. In conclusion, these Chinese herbs possess cognition-enhancing activities and anti-amnestic effects, but the mechanism of the effect of AB was different from those of OJ and CM.

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