Research ArticleNo Access

How the Cerebellum and Prefrontal Cortex Cooperate During Trace Eyeblinking Conditioning

Computational and Translational Neuroscience Laboratory (CTNLab), Institute of Cognitive Sciences and Technologies, National Research Council, Via San Martino della Battaglia 44, Rome, 00185, Italy

E-mail Address: [email protected]

Corresponding author.

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and

Pierandrea Mirino

Department of Psychology, Sapienza University of Rome, Via dei Marsi 78, Rome, 00185, Italy

E-mail Address: [email protected]

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https://doi.org/10.1142/S0129065720500410Cited by:2 (Source: Crossref)

Abstract

Several data have demonstrated that during the widely used experimental paradigm for studying associative learning, trace eye blinking conditioning (TEBC), there is a strong interaction between cerebellum and medial prefrontal cortex (mPFC). Despite this evidence, the neural mechanisms underlying this interaction are still not clear. Here, we propose a neurophysiologically plausible computational model to address this issue. The model is constrained on the basis of two critical anatomo-physiological features: (i) the cerebello-cortical organization through two circuits, respectively, targeting M1 and mPFC; (ii) the different timing in the plasticity mechanisms of these parallel circuits produced by the granule cells time sensitivity according to which different subpopulations are active at different moments during conditioned stimuli. The computer simulations run with the model suggest that these features are critical to understand how the cooperation between cerebellum and mPFC supports motor areas during TEBC. In particular, a greater trace interval produces greater plasticity changes at the slow path synapses involving mPFC with respect to plasticity changes at the fast path involving M1. As a consequence, the greater is the trace interval, the stronger is the mPFC involvement. The model has been validated by reproducing data collected through recent real mice experiments.

Keywords:

References

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