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Lateral Inhibition Organizes Beta Attentional Modulation in the Primary Visual Cortex

Department of Biomedical Physics, Institute of Experimental Physics, University of Warsaw, 5 Pasteur St, 02-093 Warsaw, Poland

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Andrzej Wróbel

Department of Neurophysiology, Nencki Institute of Experimental Biology, 3 Pasteur St, 02-093 Warsaw, Poland

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Marek Bekisz

Department of Neurophysiology, Nencki Institute of Experimental Biology, 3 Pasteur St, 02-093 Warsaw, Poland

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, and

Piotr Suffczynski

Department of Biomedical Physics, Institute of Experimental Physics, University of Warsaw, 5 Pasteur St, 02-093 Warsaw, Poland

E-mail Address: [email protected]

Corresponding author.

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https://doi.org/10.1142/S0129065718500478Cited by:3 (Source: Crossref)

Abstract

We have previously shown that during top-down attentional modulation (stimulus expectation) correlations of the beta signals across the primary visual cortex were uniform, while during bottom-up attentional processing (visual stimulation) their values were heterogeneous. These different patterns of attentional beta modulation may be caused by feed-forward lateral inhibitory interactions in the visual cortex, activated solely during stimulus processing. To test this hypothesis, we developed a large-scale computational model of the cortical network. We first identified the parameter range needed to support beta rhythm generation, and next, simulated the different activity states corresponding to experimental paradigms. The model matched our experimental data in terms of spatial organization of beta correlations during different attentional states and provided a computational confirmation of the hypothesis that the paradigm-specific beta activation spatial maps depend on the lateral inhibitory mechanism. The model also generated testable predictions that cross-correlation values depend on the distance between the activated columns and on their spatial position with respect to the location of the sensory inputs from the thalamus.

Keywords:

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