#384 : Effectiveness of Progesterone Monitoring and Rescue Protocol in Frozen Embryo Transfer Cycle

Background and aim: Hormonal monitoring impact on overall pregnancy rate in frozen embryo transfer (FET) cycles and hence progesterone supplement adjustments remain debatable in current literature. This study aims to investigate the effect of monitoring and follow-up of serum progesterone level on the day of FET, and progesterone supplement adjustments effects on pregnancy outcomes for FET in programmed hormonal replacement therapy cycles.

Methods: In this study, all patients who were scheduled for FET had their progesterone (P4) and estradiol (E2) level assessed in the morning of FEM and if their P4 level was less than 10 ng/ml, intramuscular progesterone was given for 7-10 days since the day of FET to rescue the cycle.

Results: In 2022, in Vinmec IVF center, there were in total 659 FET cycles, all was single blastocyst transfer and applied the mention protocol to rescue the cycle in case P4 level was less than 10 ng/ml. The chemical (62,87% vs 59.94%), clinical (56,68% vs 54,83%) and ongoing pregnancy rate (46,25% vs 45,17%) were comparable between the two group (with and without parenteral progesterone), P<0,05.

Conclusions: Monitor P4 level on the day of FET and use parenteral progesterone in case P4 level is less than 10 ng/ml could be an effective method to rescue the cycle and improve the outcome. Further studies are needed to draw a better conclusion and recommendation in this aspect.