Abstract
After some initial hesitancy at the beginning of the COVID-19 pandemic, the academic community agreed that the infection process is mostly airborne and generally associated with closed environments. Therefore, assessing the indoor infection probability is mandatory to contain the spread of the disease, especially in those environments, like school classrooms, hospital wards or public transportation, with higher risk of overcrowding. For this reason, we developed a software tool in Python to compute infection probability and determine those mechanisms that contribute to reduce its diffusion in closed settings. In this paper, we will briefly illustrate the model we used and focus our attention on the description of the main features of the software and give some examples of how it can be used in clinical practice to predict the spread of the disease in the rooms of a generic ward, optimize room occupancy or drive healthcare workers activity schedule. Finally, some limitations and further implementations of our work will be reported.
References
- 1. WHO, Director-General’s Opening Remarks at the Media Briefing on COVID-19, 2020. https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19—11-march-2020. Google Scholar
- 2. Center JHCR, COVID-19 Map, 2022, https://coronavirus.jhu.edu/map.html. Accessed on 14th November 2022. Google Scholar
- 3. , The airborne lifetime of small speech droplets and their potential importance to SARS-CoV-2 transmission, EPub, 2020. https://doi.org/10.1073/pnas.2006874117, https://doi.org/10.5281/zenodo.3770559, publisher: Zenodo. Google Scholar
- 4. , Outdoor transmission of SARS-CoV-2 and other respiratory viruses: A systematic review, J Infect Dis 223(4) :550–561, 2021. https://doi.org/10.1093/infdis/jiaa742. https://academic.oup.com/jid/article/223/4/550/6009483 Crossref, Web of Science, Google Scholar
- 5. , Simple quantitative assessment of the outdoor versus indoor airborne transmission of viruses and COVID-19, Environ Res 198 :111189, 2021. https://doi.org/10.1016/j.envres.2021.111189. https://linkinghub.elsevier.com/retrieve/pii/S0013935121004837 Crossref, Web of Science, Google Scholar
- 6. , Estimating COVID-19 exposure in a classroom setting: A comparison between mathematical and numerical models, Phys Fluids 33(2) :021904, 2021. https://doi.org/10.1063/5.0040755. https://aip.scitation.org/doi/10.1063/5.0040755 Crossref, Web of Science, Google Scholar
- 7. , A SARS-CoV-2 cluster in an acute care hospital, Ann Intern Med 174(6) :794–802, 2021. https://doi.org/10.7326/M20-7567. https://www.acpjournals.org/doi/10.7326/M20-7567 Crossref, Web of Science, Google Scholar
- 8. , Risk of transmission of airborne infection during train commute based on mathematical model, Environ Health Prev Med 12(2) :78–83, 2007. https://doi.org/10.1007/BF02898153. https://environhealthprevmed.biomedcentral.com/articles/10.1007/BF02898153 Crossref, Google Scholar
- 9. , Ventilation strategy for proper IAQ in existing nurseries buildings — lesson learned from the research during COVID-19 pandemic, Aerosol Air Qual Res 22(3) :210337, 2022. https://doi.org/10.4209/aaqr.210337. https://aaqr.org/articles/aaqr-21-11-covid2-0337 Crossref, Web of Science, Google Scholar
- 10. , The impact of vaccination on coronavirus disease 2019 (COVID-19) outbreaks in the United States, Clin Infect Dis 73(12) :2257–2264, 2021. https://doi.org/10.1093/cid/ciab079. https://academic.oup.com/cid/article/73/12/2257/6124429 Crossref, Web of Science, Google Scholar
- 11. , COVID-19 vaccine booster strategies for omicron SARS-CoV-2 variant: Effectiveness and future prospects, Vaccines 10(8) :1223, 2022. https://doi.org/10.3390/vaccines10081223. https://www.mdpi.com/2076-393X/10/8/1223 Crossref, Web of Science, Google Scholar
- 12. , Airborne spread of measles in a suburban elementary school, Am J Epidemiol 107(5) :421–432, 1978. https://doi.org/10.1093/oxfordjournals.aje.a112560. https://academic.oup.com/aje/article/58522/AIRBORNE Crossref, Web of Science, Google Scholar
- 13. , Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1, N Engl J Med 382(16) :1564–1567, 2020. https://doi.org/10.1056/NEJMc2004973. http://www.nejm.org/doi/10.1056/NEJMc2004973 Crossref, Web of Science, Google Scholar
- 14. , What were the historical reasons for the resistance to recognizing airborne transmission during the covid-19 pandemic? Indoor Air 32(8), 2022. https://doi.org/10.1111/ina.13070, https://onlinelibrary.wiley.com/doi/10.1111/ina.13070 Crossref, Web of Science, Google Scholar
- 15. , An overview on the role of relative humidity in airborne transmission of SARS-CoV-2 in indoor environments, Aerosol Air Qual Res 20(9) :1856–1861, 2020. https://doi.org/10.4209/aaqr.2020.06.0302. https://aaqr.org/articles/aaqr-20-06-covid-0302 Crossref, Web of Science, Google Scholar
- 16. , Effectiveness of HEPA filters at removing infectious SARS-CoV-2 from the air, mSphere 7(4) :e00086–22, 2022. https://doi.org/10.1128/msphere.00086-22. https://journals.asm.org/doi/10.1128/msphere.00086-22 Crossref, Web of Science, Google Scholar
- 17. , Airborne SARS-CoV-2 is rapidly inactivated by simulated sunlight, J Infect Dis 222(4) :564–571, 2020. https://doi.org/10.1093/infdis/jiaa334. https://academic.oup.com/jid/article/222/4/564/5856149 Crossref, Web of Science, Google Scholar
- 18. ,
Physiology, tidal volume , in StatPearls, StatPearls Publishing, 2022. http://www.ncbi.nlm.nih.gov/books/NBK482502/ Google Scholar - 19. , Outward and inward protection efficiencies of different mask designs for different respiratory activities, J Aerosol Sci 160 :105905, 2022. https://doi.org/10.1016/j.jaerosci.2021.105905. https://linkinghub.elsevier.com/retrieve/pii/S0021850221006303 Crossref, Web of Science, Google Scholar
- 20. , The facility infection risk estimator: A web application tool for comparing indoor risk mitigation strategies by estimating airborne transmission risk, Indoor and Built Environ, 1420326X2110395, 2021. https://doi.org/10.1177/1420326X211039544. http://journals.sagepub.com/doi/10.1177/1420326X211039544 Web of Science, Google Scholar
- 21. , SARS-CoV-2 transmission and the risk of aerosol generating procedures, Am J Respir Crit Care Med p. rccm.2020C11, 2020. https://doi.org/10.1164/rccm.2020C11. https://www.atsjournals.org/doi/10.1164/rccm.2020C11 Crossref, Web of Science, Google Scholar
- 22. , Virological and serological kinetics of SARS-CoV-2 delta variant vaccine breakthrough infections: A multicentre cohort study, Clin Microbiol Infect 28(4) :612.e1–612.e7, 2022. https://doi.org/10.1016/j.cmi.2021.11.010. https://linkinghub.elsevier.com/retrieve/pii/S1198743X21006388 Crossref, Web of Science, Google Scholar
- 23. , Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine, Nat Med 27(5) :790–792, 2021. https://doi.org/10.1038/s41591-021-01316-7. http://www.nature.com/articles/s41591-021-01316-7 Crossref, Web of Science, Google Scholar