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The Agricultural Model Intercomparison and Improvement Project (AgMIP) incorporates a number of major advances in the way that climate impacts, vulnerability, and adaptation are being simulated. At its core is a protocol approach that results in impact assessments being more scientifically credible and thus ultimately having greater value to the wide range of agricultural stakeholders. Moreover, the use of the protocol approach enables closer scrutiny and intercomparison of models and methods so that they can be improved over time. By creating a truly trans-disciplinary, systems-based approach, AgMIP impact assessments and evaluation of adaptations become useful to agricultural decision-makers at multiple scales. The chapters in this two-part set demonstrate the use of this approach and represent early steps towards the full realization of these new methods and their application.